Static Analysis for ECMAScript String Manipulation Programs

In recent years, dynamic languages, such as JavaScript or Python, have been increasingly used in a wide range of fields and applications. Their tricky and misunderstood behaviors pose a great challenge for static analysis of these languages. A key aspect of any dynamic language program is the multiple usage of strings, since they can be implicitly converted to another type value, transformed by string-to-code primitives or used to access an object-property. Unfortunately, string analyses for dynamic languages still lack precision and do not take into account some important string features. In this scenario, more precise string analyses become a necessity. The goal of this paper is to place a first step for precisely handling dynamic language string features. In particular, we propose a new abstract domain approximating strings as finite state automata and an abstract interpretation-based static analysis for the most common string manipulating operations provided by the ECMAScript specification. The proposed analysis comes with a prototype static analyzer implementation for an imperative string manipulating language, allowing us to show and evaluate the improved precision of the proposed analysis

Recipient Outcomes after ABO-Incompatible Liver Transplantation: A Systematic Review and Meta-Analysis

BACKGROUND: ABO-incompatible live transplantation (ILT) is not occasionally performed due to a relative high risk of graft failure. Knowledge of both graft and patient survival rate after ILT is essential for donor selection and therapeutic strategy. We systematically reviewed studies containing outcomes after ILT compared to that after ABO-compatible liver transplantation (CLT). METHODOLOGY/PRINCIPAL FINDINGS: We carried out a comprehensive search strategy on MEDLINE (1966-July 2010), EMBASE (1980-July 2010), Biosis Preview (1969-July 2010), Science Citation Index (1981-July 2010), Cochrane Database of Systematic Reviews (Cochrane Library, issue 7, 2010) and the National Institute of Health (July 2010). Two reviewers independently assessed the quality of each study and abstracted outcome data. Fourteen eligible studies were included which came from various medical centers all over the world. Meta-analysis results showed that no significantly statistical difference was found in pediatric graft survival rate, pediatric and adult patient survival rate between ILT and CLT group. In adult subgroup, the graft survival rate after ILT was significantly lower than that after CLT. The value of totally pooled OR was 0.64 (0.55, 0.74), 0.92 (0.62, 1.38) for graft survival rate and patient survival rate respectively. The whole complication incidence (including acute rejection and biliary complication) after ILT was higher than that after CLT, as the value of totally pooled OR was 3.02 (1.33, 6.85). Similarly, in acute rejection subgroup, the value of OR was 2.02 (1.01, 4.02). However, it was 4.08 (0.90, 18.51) in biliary complication subgroup. CONCLUSIONS/SIGNIFICANCE: In our view, pediatric ILT has not been a contraindication anymore due to a similar graft and patient survival rate between ILT and CLT group. Though adult graft survival rate is not so satisfactory, ILT is undoubtedly life-saving under exigent condition. Most studies included in our analysis are observational researches. Larger scale of researches and Randomized-Control Studies are still needed

Drug Nanocrystals for Active Tumor-Targeted Drug Delivery

Drug nanocrystals, which are comprised of active pharmaceutical ingredients and only a small amount of essential stabilizers, have the ability to improve the solubility, dissolution and bioavailability of poorly water-soluble drugs; in turn, drug nanocrystal technology can be utilized to develop novel formulations of chemotherapeutic drugs. Compared with passive targeting strategy, active tumor-targeted drug delivery, typically enabled by specific targeting ligands or molecules modified onto the surface of nanomedicines, circumvents the weak and heterogeneous enhanced permeability and retention (EPR) effect in human tumors and overcomes the disadvantages of nonspecific drug distribution, high administration dosage and undesired side effects, thereby contributing to improving the efficacy and safety of conventional nanomedicines for chemotherapy. Continuous efforts have been made in the development of active tumor-targeted drug nanocrystals delivery systems in recent years, most of which are encouraging and also enlightening for further investigation and clinical translation

Meta-analysis results of patient survival rate.

<p>Meta-analysis results of patient survival rate.</p

Meta-analysis results.

a<p>Random-effects model.</p

Meta-analysis results of graft survival rate.

<p>Meta-analysis results of graft survival rate.</p

Egger test results of studies on patient survival rate.

<p>Egger test results of studies on patient survival rate.</p

Egger test results of studies on complication incidence.

<p>Egger test results of studies on complication incidence.</p

Meta-analysis results of complication incidence.

<p>Meta-analysis results of complication incidence.</p